Modeling Immunological Networks in an Educational Setting using Cell Collective

Abstract One challenge in the teaching of immunology is complexity subject. Immunology presents a long list unique cells, signaling molecules, receptor-ligand interactions, regulatory mechanisms, developmental pathways, and outcomes that can feel burdensome to instructors unapproachable students. The beauty this subject, however, these features interact networks parallel those other biological fields. Visualizing interactions between tissues, molecules immune system their promote immunological literacy broad understanding systems. Cell Collective (cellcollective.org) an open-access, approachable software allows students researchers alike build models perform simulations processes. Students use interactive platform probe cell-cell metabolic networks, etc. while building systems thinking computational skills, which are critical for success STEM After models, real-time be run visualize understand dynamics under conditions environmental pressure, disease, mutation, Instructors assess student knowledge by assessments into modules formative or summative manner. Because it free, user-friendly, offers host pre-built training, educational experimental modules, ideally suited all types settings. Supported grant from NSF (RCN-UBE) 2120806